Research
The NLRP3 Inflammasome Instigates Obesity-Induced Inflammation and Insulin Resistance
Abstract This publication demonstrates that the Nlrp3 inflammasome senses obesity–associated ‘danger–signals’ and contributes to obesity–induced inflammation and insulin resistance. Citation Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nature Medicine 17:179-88. PMID: 21217695. PMCID: PMC3076025. Read More: Nature Medicine Research Details Research Center: Pennington Biomedical Research Center Related Research Grants: R01 DK090556, R01 AG31797, R00 DK083615, P20 RR021945 Center Contribution: The flow cytometry to analyze adipose tissue macrophages, resident effector T cells and regulatory T cells, documentation by microscopy, evaluation of … Read More »
Categories: Publications Tags: Pennington Biomedical Research CenterAltered Gene Expression and Spongiotrophoblast Differentiation in Placenta from a Mouse Model of Diabetes in Pregnancy
Abstract Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. This paper details the changes in the mouse placenta as a consequence of maternal diabetes during pregnancy. Citation Salbaum JM, Kruger C, Zhang X, Delahaye NA, Pavlinkova G, Burk DH, Kappen C. Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy. Diabetologia. 2011 Jul;54(7):1909-20. PMCID: PMC3882064. Read More: Diabetologia Research Details Research Center: Pennington Biomedical Research Center Related Research Grants: R01 HD037804, R01 HD055528, P20 … Read More »
Categories: Publications Tags: Pennington Biomedical Research Center