This paper queries the causal links between systemic inflammation and aging, and details a mechanism by which the Nlrp3 inflammasome controls systemic low-grade age-related “sterile” inflammation. Ablation of Nlrp3 inflammasome protected mice from age-related increases in the innate immune activation, alterations in CNS transcriptome, astrogliosis, and improved glycemic control, and attenuated both bone loss and thymic demise.
- Youm YH, Grant RW, McCabe LR, Albarado DC, Nguyen KY, Ravussin A, Pistell P, Newman S, Carter R, Laque A, Münzberg H, Rosen CJ, Ingram DK, Salbaum JM, Dixit VD. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013 Oct 1;18(4):519-32. PMCID: PMC4017327.
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- Research Center: Pennington Biomedical Research Center
- Related Research Grants: R01 DK090556, R56 AI105097, R01 AG043608, R01 HD055528
- Center Contribution: Resources available in the Molecular Mechanisms Core, in particular flow cytometry, western blot scanning, confocal microscopy, microarray analysis and systems biology evaluation, as well as gene expression measurements via qPCR, were utilized to carry out the studies reported in the paper.