This publication demonstrates that the Nlrp3 inflammasome senses obesity–associated ‘danger–signals’ and contributes to obesity–induced inflammation and insulin resistance.
- Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nature Medicine 17:179-88. PMID: 21217695. PMCID: PMC3076025.
Read More: Nature Medicine
- Research Center: Pennington Biomedical Research Center
- Related Research Grants: R01 DK090556, R01 AG31797, R00 DK083615, P20 RR021945
- Center Contribution: The flow cytometry to analyze adipose tissue macrophages, resident effector T cells and regulatory T cells, documentation by microscopy, evaluation of western blots, and measurements of gene expression using qPCR were all carried out in the Pennington Molecular Mechanisms Core.