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Abstract

This publication demonstrates that the Nlrp3 inflammasome senses obesity–associated ‘danger–signals’ and contributes to obesity–induced inflammation and insulin resistance.

Citation

Read Morebullet pointNature Medicine


Research Details

  • Research Center: Pennington Biomedical Research Center
  • Related Research Grants: R01 DK090556, R01 AG31797, R00 DK083615, P20 RR021945
  • Center Contribution: The flow cytometry to analyze adipose tissue macrophages, resident effector T cells and regulatory T cells, documentation by microscopy, evaluation of western blots, and measurements of gene expression using qPCR were all carried out in the Pennington Molecular Mechanisms Core.

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