Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. This paper details the changes in the mouse placenta as a consequence of maternal diabetes during pregnancy.
- Salbaum JM, Kruger C, Zhang X, Delahaye NA, Pavlinkova G, Burk DH, Kappen C. Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy. Diabetologia. 2011 Jul;54(7):1909-20. PMCID: PMC3882064.
- Research Center: Pennington Biomedical Research Center
- Related Research Grants: R01 HD037804, R01 HD055528, P20 RR021945, G20 RR024838
- Center Contribution: Supporting data were generated in the Molecular Mechanisms Core: microarray gene expression and systems biology analysis, tissue-level expression via in situ hybridization, documentation using the Nanozoomer, and image analysis in ImageJ.
This paper also represents one of the first instances in the Molecular Mechanisms Core where a quantitative approach to histology, facilitated by high-throughput slide scanning, yielded significant new biological insights on the diabetic placenta – reduced junctional and labyrinth layers accompanied by aberrant differentiation of spongiotrophoblast cells – that would not have been possible by traditional histological observation of single images.