Skip to main content

NORCH Bulletin January 2020

January 27, 2020

NORCH Newsletter January 2020 (Issue #19)

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

NORCH Bulletin November 2019

November 21, 2019

NORCH Newsletter November 2019 (Issue #18)

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

NORCH Bulletin September 2019

October 18, 2019

NORCH Bulletin September 2019 (Issue #17)

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle‐aged women is not caused by leucine alone

October 18, 2019

Abstract It has been suggested that leucine is primarily responsible for the increase in muscle protein synthesis (MPS) after protein ingestion because leucine uniquely activates the mTOR‐p70S6K signalling cascade. We tested this hypothesis by measuring muscle p‐mTORSer2448, p‐p70S6KThr389 and p‐eIF2αSer51, as well as protein turnover (by stable isotope labelled amino acid tracer infusion in conjunction with leg arteriovenous blood and muscle tissue sampling), in 28 women who consumed either 0.45 g protein kg−1 fat‐free mass (containing 0.0513 g leucine kg−1 fat‐free mass) or a control drink (n = 14) or 0.0513 g leucine kg−1 fat‐free mass or a control drink (n = 14) during a hyperinsulinaemic‐euglycaemic clamp procedure … Read More »

Categories: Featured News, News, Publications Tags: Washington University St. Louis

Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial

October 18, 2019

Abstract Objective Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. Methods Forty people with obesity (BMI=37.9±4.3 kg/m2) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-2H2]glucose tracer infusion was used to assess glucose kinetics. Results At baseline, fasting … Read More »

Categories: Featured News, News, Publications Tags: Washington University St. Louis

Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People

October 18, 2019

Abstract Context Many biological pathways involved in regulating substrate metabolism display rhythmic oscillation patterns. In rodents, clock genes regulate circadian rhythms of metabolic genes and substrate metabolism. However, the interrelationships among substrate metabolism, metabolic genes, and clock genes have not been fully explored in people. Objective We tested the hypothesis that the diurnal expression pattern of pyruvate dehydrogenase kinase 4 (PDK4), a key metabolic enzyme involved in fuel switching between glucose and free fatty acids (FFAs), is associated with plasma FFA concentration and clock genes. Design and Methods We analyzed peripheral blood mononuclear cells (PBMCs), subcutaneous adipose tissue, and plasma … Read More »

Categories: Featured News, News, Publications Tags: Washington University St. Louis

NORCH Bulletin June 2019

September 6, 2019

NORCH Bulletin June 2019 (Issue #16)          

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

NORCH Bulletin April 2019

April 5, 2019

NORCH Bulletin April 2019 Research Spotlight:                                                                                                                          SGLT2 Inhibition Reprograms Systemic Metabolism via FGF21-Dependent and – Independent Mechanisms  Sodium/glucose cotransporter-2 (SGLT2) inhibitors are a relatively new class of antidiabetic medications that inhibit renal glucose reabsorption, increasing glucosuria and lowering serum glucose. More recently, SGLT2 … Read More »

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

NORCH Bulletin February 2019

February 18, 2019

  NORCH Bulletin February 2019 Featured: Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA.  Acarbose improves health and lifespan in aging HET3 mice.  Aging Cell. 2019 Jan 27:e12898.   This edition’s featured paper highlights the work of Richard Miller, MD, PhD, one of the speakers at our upcoming Annual Symposium, Longevity and Aging: Nutritional and Metabolic Mechanisms.    Acarbose inhibits alpha-glucosidase, reducing the rate of digestion of polysaccharides and blunding … Read More »

Categories: Featured News, News, Newsletters Tags: Harvard Medical School

Michigan Nutrition Obesity Research Center Annual Symposium

January 25, 2019

The MNORC symposium provides a forum for intellectual exchange on topics related to obesity, nutrition and metabolomics among established investigators, junior faculty, students and other researchers at the University and surrounding area.   Click here to REGISTER

Categories: News Tags: University of Michigan