The Genomics Core Facility seeks to achieve high quality research data production through education of core facility users, optimal use of qPCR and RNA/DNA quality and quantity instrumentation, and quality Sanger sequencing, next-generation sequencing, robotics, and microarray services. Take a … Read more

Abstract This prospective cohort study suggests that adherence to a low risk lifestyle before pregnancy is associated with a low risk of gestational diabetes and could be an effective strategy for the prevention of gestational diabetes. Key Findings Adherence to … Read more

Researchers at Pennington Biomedical Research Center have discovered a new pathway that controls how our bodies respond to a diet that’s low in protein. This finding could improve treatments for obesity and diabetes. Data collected by Chris Morrison, PhD and … Read more

Abstract Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. We show that circulating FGF21 levels are increased by dietary protein restriction, but not energy restriction, via a mechanism that includes … Read more

Abstract This study followed 52,682 women aged 46–71 years in the Nurses’ Health Study (in 1992–2000) and 52,587 women aged 29–46 years in the Nurses’ Health Study II (in 1993–2001). Body weight was self-reported, Health-related quality of life (HRQoL) was … Read more

Abstract Brown fat can reduce obesity through the dissipation of calories as heat. Control of thermogenic gene expression occurs via the induction of various coactivators, most notably PGC-1α. In contrast, the transcription factor partner(s) of these cofactors are poorly described. … Read more

Abstract Lipolysis regulates energy homeostasis through the hydrolysis of intracellular triglycerides and the release of fatty acids for use as energy substrates or lipid mediators in cellular processes. Genes encoding proteins that regulate energy homeostasis through lipolysis are thus likely … Read more

Abstract A mutation in a fat-storage gene has been identified that appears to increase the risk for type 2 diabetes and other metabolic disorders, according to a study. Type 2 diabetes is a complex disease whose susceptibility is often determined … Read more

Abstract In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters systemic insulin sensitivity. Here we show, using DNA array analyses, that nicotinamide N-methyltransferase (Nnmt) is the most … Read more

Abstract Mice and humans lacking caveolae have numerous pathologies including markedly aberrant fuel metabolism, lipodystrophy, and muscular dystrophy. Characterization of the physiologic/metabolic profile of cavin-1 knock-out mice suggests that dysfunction in fat, muscle, and liver metabolism in cavin-1-null mice causes … Read more