A new University of Colorado Anschutz Medical Campus study finds that hormones in breast milk may impact the development of healthy bacteria in infants’ guts, potentially protecting them from intestinal inflammation, obesity and other diseases later in life. The study, … Read more

The UNC Nutrition Obesity Research Center (NORC) will receive a $5.4 million grant from the National Institutes of Health (NIH) to fund another five years of research. The award is the fourth time NIH has provided five-year funding for the … Read more

Concerns about rigor in science, particularly obesity research, have been raised in recent years, and a movement is underway to proactively help investigators structure the design and reproducibility of their science. A paper from investigators at the University of Alabama … Read more

Abstract Increased circulating free fatty acids (FFAs) have been proposed to contribute to insulin resistance in obesity. Short-term studies have investigated the effects of acipimox, an inhibitor of hormone-sensitive lipase, on glucose homeostasis, but longer-term studies have not been performed. … Read more

Abstract Hypothalamic proopiomelanocortin (POMC) is essential for the physiological regulation of energy balance; however, its role in glucose homeostasis remains less clear. We show that hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe obesity and insulin resistance, unexpectedly exhibit improved … Read more

Abstract Modern scientific inquiries require significant data-driven evidence and trans-disciplinary expertise to extract valuable information and gain actionable knowledge about natural processes. Effective evidence-based decisions require collection, processing and interpretation of vast amounts of complex data. The Moore’s and Kryder’s … Read more

Summary Elevated levels of circulating triglycerides are a risk factor for ischemic cardiovascular disease, and activation of lipoprotein lipase, an enzyme that is inhibited by angiopoietin-like 4 (ANGPTL4), has been shown to reduce levels of circulating triglycerides. In this study the … Read more

Child obesity more than doubled between 1980 and 2012, and the Centers for Disease Control and Prevention calls it an “epidemic.” But what if video games could actually help kids lose weight? A new study by a group of Louisiana … Read more

Abstract Increased maternal body mass index (BMI) is a robust risk factor for later pediatric obesity. Accumulating evidence suggests that human milk (HM) may attenuate the transfer of obesity from mother to offspring, potentially through its effects on early development … Read more

Abstract FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that … Read more